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[Sheldon's hot twin sister, Missy, is in town for a wedding]
Leonard Hofstadter: If the wedding's not until tomorrow, why don't you stay with us tonight?
Missy: Oh, I don't think so. Shelly doesn't like company. Even as a little boy, he'd send his imaginary friends home at the end of the day.
Sheldon Cooper: They were not "friends". They were imaginary colleagues.

Penny: So, Sheldon's sister is pretty cute.
Leonard Hofstadter: I wasn't staring!
Penny: I didn't say you were; I just said she was cute.
Leonard Hofstadter: Oh! Uh, maybe... if you like women who are tall... and perfect.

Penny: Sheldon, why are you ignoring your sister?
Sheldon: I'm not ignoring my sister. I'm ignoring all of you.

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