| Academy Awards, USA | |||
| Year | Result | Award | Category/Recipient(s) |
|---|---|---|---|
| 1992 | Nominated | Oscar |
Best Actress in a Leading Role for: Rambling Rose (1991) |
| Academy of Science Fiction, Fantasy & Horror Films, USA | |||
| Year | Result | Award | Category/Recipient(s) |
| 1994 | Nominated | Saturn Award |
Best Actress for: Jurassic Park (1993) |
| Boston Society of Film Critics Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 2004 | Won | BSFC Award |
Best Supporting Actress for: We Don't Live Here Anymore (2004) Tied with Sharon Warren for Ray (2004/I). |
| Chlotrudis Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 2007 | Nominated | Chlotrudis Award |
Best Actress for: Inland Empire (2006) |
| Emmy Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 2008 | Nominated | Emmy |
Outstanding Supporting Actress in a Miniseries or a Movie for: Recount (2008) (TV) |
| 1997 | Nominated | Emmy |
Outstanding Guest Actress in a Comedy Series for: "Ellen" (1994) For playing "Susan Richmond". For "The Puppy Episode". |
| 1994 | Nominated | Emmy |
Outstanding Guest Actress in a Drama Series for: "Fallen Angels" (1993) For playing "Annie Ainsley". For episode "Murder, Obliquely". |
| 1992 | Nominated | Emmy |
Outstanding Lead Actress in a Miniseries or a Special for: Afterburn (1992) (TV) |
| Golden Globes, USA | |||
| Year | Result | Award | Category/Recipient(s) |
| 1999 | Nominated | Golden Globe |
Best Performance by an Actress in a Mini-Series or Motion Picture Made for TV for: The Baby Dance (1998) (TV) |
| 1993 | Won | Golden Globe |
Best Performance by an Actress in a Mini-Series or Motion Picture Made for TV for: Afterburn (1992) (TV) |
| 1992 | Nominated | Golden Globe |
Best Performance by an Actress in a Motion Picture - Drama for: Rambling Rose (1991) |
| 1982 | - | Miss Golden Globe | |
| Independent Spirit Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 2007 | Won | Special Distinction Award |
Shared with: David Lynch For their collaborative work. |
| 1987 | Nominated | Independent Spirit Award |
Best Female Lead for: Blue Velvet (1986) |
| 1986 | Nominated | Independent Spirit Award |
Best Female Lead for: Smooth Talk (1985) |
| Los Angeles Film Critics Association Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 1985 | Won | New Generation Award | |
| Montréal World Film Festival | |||
| Year | Result | Award | Category/Recipient(s) |
| 1996 | Won | Best Actress |
for: Citizen Ruth (1996) |
| 1991 | Won | Best Actress |
for: Rambling Rose (1991) Tied with Hye-suk Lee in Eunmaneun oji anhneunda (1991). |
| Satellite Awards | |||
| Year | Result | Award | Category/Recipient(s) |
| 1997 | Nominated | Golden Satellite Award |
Best Performance by an Actress in a Mini-Series or Motion Picture Made For Television for: The Siege at Ruby Ridge (1996) (TV) |
| Sundance Film Festival | |||
| Year | Result | Award | Category/Recipient(s) |
| 1999 | - | Tribute to Independent Vision Award | |